Research & Evaluation: NIH/NIDA/CTN
Overview | NIATx | Research Projects

NIDA CTN Studies we have been a part of:

CTN 5- Motivational Interviewing

The Motivational Interviewing (MI) protocol will compare the efficacy of one session using motivational interviewing techniques versus a standard treatment intake interview. The MET protocol will compare three therapy sessions using Motivational Interviewing techniques versus standard treatment. The primary outcome measure is retention in treatment and reduction of drug use during and post-treatment.*

CTN 17- HIV and HCV Risk Reduction Interventions in Drug Detoxification and Treatment Settings

The connection between AIDS and drug injection is well established. Through June 2000, injection drug users accounted for more than a third of all cases reported among persons aged 13 or older to the Centers for Disease Control and Prevention. Hepatitis C virus (HCV), transmitted primarily through sharing drug preparation and injection equipment, is also a major public health concern.

Sixty percent of HCV transmission is related to injection drug use and as many as 50-95% of injection drug users are infected with HCV. This study tests two strategies to reduce the risk of contracting HIV or HCV by reducing risk behaviors in patients undergoing drug detoxification. The first includes pre-test counseling, testing, post-test counseling, and the provision of HIV/HCV results. The second strategy, called therapeutic alliance, provides clients with information to guide them through the process of role induction and aims to facilitate transition to continuing care for drug treatment. Both will be compared to standard care in drug detoxification settings.*

CTN 31- Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use by Increasing 12-Step Involvement

The primary objective of this protocol is to evaluate the degree to which a combined group and individual 12-Step facilitative intervention, Stimulant Abuser Groups to Engage in 12 -Step (STAGE-12), improves substance -related outcomes compared to treatment as usual (TAU) without STAGE-12 among stimulant abusers. The primary objective is to evaluate reduction in percent of days of stimulant use as measured by self-report. Secondary objectives include evaluating reduction in percent days of use of other substances, the degree to which STAGE-12 increases involvement in 12-step activities and attendance at 12-step meetings, and the extent to which such 12 –step involvement and meeting attendance mediate substance use outcomes. A total of approximately 400 stimulant users seeking formal treatment, recruited from approximately 9 CTPS, will be randomized to STAGE-12 or TAU.*

CTN 31A- An evaluation of neurocognitive function, oxidative damage, and their association with treatment outcomes in methamphetamine and cocaine abusers.

The primary objective of this study is to replicate the finding that performance on the Stroop color-word interference task is predictive of treatment completion in participants with cocaine use disorders and to extend this finding to participants with METH use disorders.  Secondary objectives include evaluating whether: 1. performance on various neurocognitive tests... is predictive of
treatment attrition and stimulant use outcomes in METH/cocaine abusers; 2. neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers; 3. oxidative damage, as assessed by two plasma measures, is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers, and 4.  oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group 

Current Study-
CTN 44-

The principal objective of the study is to evaluate the effectiveness of including an interactive, web-based psychosocial intervention plus incentives targeting drug/alcohol abstinence and treatment participation as part of community-based, outpatient substance abuse treatment.  Individuals accepted in outpatient treatment for substance use disorders (excluding those receiving opioid pharmacotherapy for opioid dependence) will be eligible to participate.

The information from this page identified with an * were found at this site:

SAMHSA Grants- 
CSAT Adolescent Residential Treatment Grant #TI-14271 


A full continuum of services, from residential through outpatient to
aftercare, provides adolescent female clients with long-term connections to caring staff and the healing principles of feminine-based recovery. 

Girls who are pregnant or who have children are able to access
treatment services along with prenatal care, parent training, and the
Child Development Center. Eight residential beds were funded by this
grant. Data collection using the Global Appraisal of Individual Needs
assessment began in February 2003 and was completed September
2005. Participants ranged in age from 12 to 18 with each completing a
baseline, 3, 6, and 12 month follow up sessions. 

NIH Grants- 
NIH Addressing Tobacco Through Organizational Change 

2006– 2008

The Research Department conducted a study, “Addressing Tobacco
Through Organizational Change” in conjunction with the University of
California at San Francisco. This NIH funded grant was an organizational change project focused on tobacco cessation for WF staff and clients. A Tobacco Leadership Committee has been formed at WF that changed policies and procedures as well as to involve all staff in making lasting changes at Willamette Family.

The goal was to become a smoke free agency by February 1, 2007.  Staff and clients were offered Nicotine Replacement Therapy as well as group therapy and support groups to work on quitting smoking.  The Research Department has developed a tracking system to monitor NRT disbursement.  Although UCSf is overseeing the data collection, the WF Research Department will assist with recruitment and incentive reimbursement. 






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